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Circulating SARS-CoV-2 Vaccine Antigen Detected in the Plasma of mRNA-1273 Vaccine Recipients
Abstract SARS-CoV-2 proteins were measured in longitudinal plasma samples collected from 13 participants who received two doses of mRNA-1273 vaccine. 11 of 13 participants showed detectable levels of SARS-CoV-2 protein as early as day one after first vaccine injection. Clearance of detectable SARS-CoV-2 protein correlated with production of IgG and IgA. https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciab465/6279075?fbclid=IwAR22xjnzsC0ayKSA5Z63CReAXzK2Od0M8P0Rx-Yq6n3Pwteopl0amqU1G-o Q. Do Vaccines Disappear in Body after 2-3 Days? A. This submitted and accepted paper shows at least 30 days Q. Is this a big study A. No Only 13 people. Things to note: S1 antigen was detected as early as day one post vaccination and peak levels were detected on average five days after the first injection. For one individual (Participant #8), spike was detected at day 29, one day after the second injection and was undetec...
Vaccines Spike Protein: Risk of rapid evolutionary escape from biomedical interventions targeting SARS-CoV-2 spike protein
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0250780 The spike protein receptor-binding domain (RBD) of SARS-CoV-2 is the molecular target for many vaccines and antibody-based prophylactics aimed at bringing COVID-19 under control. Such a narrow molecular focus raises the specter of viral immune evasion as a potential failure mode for these biomedical interventions. With the emergence of new strains of SARS-CoV-2 with altered transmissibility and immune evasion potential, a critical question is this: how easily can the virus escape neutralizing antibodies (nAbs) targeting the spike RBD? To answer this question, we combined an analysis of the RBD structure-function with an evolutionary modeling framework. Our structure-function analysis revealed that epitopes for RBD-targeting nAbs overlap one another substantially and can be evaded by escape mutants with ACE2 affinities comparable to the wild type, that are observed in sequence surveillance data and infect cel...

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