https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516275/ RESEARCH ARTICLE Imperfect Vaccination Can Enhance the Transmission of Highly Virulent Pathogens Andrew F. Read1,2*, Susan J. Baigent3 , Claire Powers3 , Lydia B. Kgosana3 , Luke Blackwell3 , Lorraine P. Smith3 , David A. Kennedy1,2, Stephen W. Walkden-Brown4 , Venugopal K. Nair3 1 Center for Infectious Disease Dynamics, Departments of Biology and Entomology, The Pennsylvania State University, University Park, Pennsylvania, United States of America, 2 Fogarty International Center, National Institutes of Health, Bethesda, Maryland, United States of America, 3 Avian Oncogenic Virus Group, The Pirbright Institute, Compton, Newbury, Berkshire, United Kingdom, 4 School of Environmental and Rural Science, The University of New England, Armidale, Australia * a.read@psu.edu Abstract Could some vaccines drive the evolution of more virulent pathogens? Conventional wisdom is that natural selection will remove highly lethal pathogens if ho...
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